منابع مشابه
ICT PD 4 Me!
Researchers and practitioners recognise the crucial links between ICT Access and ICT Ability in promoting ICT Use. This paper is the third in a series exploring this link, and concentrates specifically on approaches to ICT Ability. This paper considers literature and research relating to ICT PD from a variety of sources and countries. Building on a model proposed at the ITEM2002 conference, the...
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The cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) immune checkpoints are negative regulators of T-cell immune function. Inhibition of these targets, resulting in increased activation of the immune system, has led to new immunotherapies for melanoma, non-small cell lung cancer, and other cancers. Ipilimumab, an inhibitor of CTLA-4, is approved for the treatme...
متن کامل[(Pd-Pd)@Ge18]4-: a palladium dimer inside the largest single-cage deltahedron.
The largest single-cage deltahedral cluster is made of 18 germanium atoms and is centered by a pair of palladium atoms. Its shape is very close to the ideal D3d symmetry expected and predicted for a cluster of this size.
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The palladium(II) chlorostibine complex [PdCl2(SbMe2Cl)2]2 has a dimeric structure in the solid state, stabilized by hyper-coordination at the Lewis amphoteric Sb centers. Reaction with 8 equiv of MeLi forms [Pd4(μ3-SbMe3)4(SbMe3)4], whose structure comprises a tetrahedral Pd(0) core with four terminal SbMe3 ligands and four μ3-SbMe3 ligands, one capping each triangular Pd3 face. Density functi...
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Immune checkpoint blockade with monoclonal antibodies directed at the inhibitory immune receptors CTLA-4, PD-1, and PD-L1 has emerged as a successful treatment approach for patients with advanced melanoma. Ipilimumab is the first agent associated with a documented improved overall survival benefit in this patient population. A striking attribute of CTLA-4 blockade is the durability of objective...
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ژورنال
عنوان ژورنال: Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
سال: 2015
ISSN: 0030-1558,1882-4528
DOI: 10.4044/joma.127.63